Certain antibiotics have the potential to increase seizures in susceptible dogs.  It's important to understand that this does not mean that these medications  should be avoided in epileptic dogs.  On occasion, a medication that has the potential to lower the seizure threshold, is the best medication to treat an infection.  The risk of infection will always be weighed against the risk of seizures in these cases.

Please note that every dog reacts to medications differently and the following guidelines may not apply to your dog.

In general, these drugs have little risk of seizures.

Penicillins and cephalosporins are usually safe, although high doses may exacerbate seizures.  These drugs include:

Sulfonamides and Metronidazole (Flagyl) carry a small risk of seizures.

In addition to the potential to lower the seizure threshold, your vet will consider potential drug interactions with the anti-seizure medication that is used.